Causes for Myasthenic Crisis

Myasthenic crisis is a life-threatening exacerbation of myasthenia gravis (MG) characterized by worsening of myasthenic weakness that requires intubation or noninvasive ventilation. Let’s explore the causes and triggers of myasthenic crisis:


1. Respiratory Infections: Fevers, coughs, colds, and lung infections (such as pneumonia) can trigger a myasthenic crisis.

2. Surgery: surgical interventions as well as the associated anesthesia can lead to a crisis.

3. Thymus Tumor: A tumor of the thymus (a gland in your chest) may contribute to a crisis.

4. Aspiration Pneumonitis: Breathing in stomach acid or vomit (aspiration pneumonitis) can worsen symptoms.

5. Thyroid Disease: Thyroid disorders may play a role in precipitating a crisis.

6. Medication Changes: Alterations in medications can impact MG symptoms and potentially lead to a crisis.

7. Monthly Periods or Pregnancy: Hormonal changes during menstruation or pregnancy may affect MG.

8. Stress: Trauma, surgery, emotional upset, and stress can exacerbate myasthenia gravis.

9. Contrast Dyes: Some contrast dyes used in imaging tests (such as CT scans or MRIs) may be associated with crisis.



(1) Myasthenic Crisis – What You Need to Know –
(2) What Is a Myasthenic Crisis and How to Avoid It – Healthline.
(3) Myasthenic crisis – UpToDate.
(4) Myasthenia gravis – Symptoms and causes – Mayo Clinic.
(5) Myasthenia Gravis – National Institute of Neurological Disorders and Stroke.
(6) Myasthenia Gravis | Johns Hopkins Medicine.
(7) undefined.

Verified by Dr. Petya Stefanova