Is amyotrophic lateral sclerosis (ALS) associated with genetic factors?

Correct answer is C. Approximately 5–10% of ALS cases occur within families, which is known as familial ALS. In these cases, two or more family members have ALS, and the condition is caused by several inherited factors, with the most common being a mutation in the SOD1 gene1. However, the majority of ALS cases (about 85%) do not have a single genetic cause, and the exact pathophysiology of the disease remains incompletely understood.