# Case Steven Q9: The patient, a 68-year-old male, presents with acute ischemic stroke symptoms that began 1 hour ago. His weight is 80 kg, and his height is 175 cm. His blood pressure is 185/90 mmHg, and his blood glucose level is 8 mmol/L. Based on these details, what is the correct dose of intravenous tissue plasminogen activator (tPA) to administer?

#### Case Steven Q9: The patient, a 68-year-old male, presents with acute ischemic stroke symptoms that began 1 hour ago. His weight is 80 kg, and his height is 175 cm. His blood pressure is 185/90 mmHg, and his blood glucose level is 8 mmol/L. Based on these details, what is the correct dose of intravenous tissue plasminogen activator (tPA) to administer?

Correct answer is B: 72 mg The dose of intravenous tPA for the treatment of acute ischemic stroke is calculated based on the patient's weight. The standard dosing regimen for tPA is 0.9 mg/kg, with a maximum dose of 90 mg. Calculate the Total Dose: The patient's weight is 80 kg. The dose of tPA is 0.9 mg/kg. Total dose = 0.9  mg/kg × 80  kg = 72  mg Total dose=0.9 mg/kg×80 kg=72 mg Determine the Bolus and Infusion: 10% of the total dose is given as an initial bolus over 1 minute. The remaining 90% is administered as an infusion over 60 minutes. For a total dose of 72 mg: Bolus Dose: 10% of 72 mg = 7.2 mg Infusion Dose: 90% of 72 mg = 64.8 mg (administered over 60 minutes)

Verified by Dr. Petya Stefanova