{"version":"1.0","provider_name":"Knowlaxy","provider_url":"https:\/\/knowlaxy.com\/bg","title":"Q 2.29. Spinal Muscular Atrophy (SMA) - Knowlaxy","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"SkL1IhdNEa\"><a href=\"https:\/\/knowlaxy.com\/bg\/summaries\/q-2-29-spinal-muscular-atrophy-sma\/\">Q 2.29. Spinal Muscular Atrophy (SMA)<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/knowlaxy.com\/bg\/summaries\/q-2-29-spinal-muscular-atrophy-sma\/embed\/#?secret=SkL1IhdNEa\" width=\"600\" height=\"338\" title=\"&#8220;Q 2.29. Spinal Muscular Atrophy (SMA)&#8221; &#8212; Knowlaxy\" data-secret=\"SkL1IhdNEa\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n<\/script>","description":"Definition and Background: SMA is an\u00a0autosomal recessive inherited disease\u00a0that primarily affects\u00a0anterior horn cells\u00a0in the spinal cord. The estimated incidence is\u00a01 in 6,000 to 10,000 live births. Clinically, patients present with\u00a0hypotonia\u00a0and\u00a0progressive symmetric, proximal weakness, typically sparing the facial muscles and diaphragm. Most individuals with SMA have a\u00a0homozygous deletion of at least exon 7 on the SMN1 [&hellip;]"}